An Expanded Notch-Delta Model Exhibiting Long-Range Patterning and Incorporating MicroRNA Regulation
Figure 8
The microRNA miR-124 modulates the Notch decay rate.
(A) Representative embryo for miR-124 titration experiments. (B) Magnified region of the embryo in (A) shows adjacent ESNs; DAPI staining shows pairs of small nuclei belonging to the ESN pairs. (C–D) Comparison of the distribution of ESN counts and spacing between miR-124 titration experiments and our model. Based on this data and our previous results [33], [34], we propose that the Notch decay rate, , is modulated by miR-124.