Quantifying and Predicting the Effect of Exogenous Interleukin-7 on CD4+T Cells in HIV-1 Infection
Figure 5
Simulated trajectories of CD4+ T cell dynamics over 2 years for patient #1 with repeated IL-7 injections.
Simulated treatment is based on CD4+ T cell count measurements (Triangles are the observed values) every three months (grey dashed vertical lines). If the count drops below 500 cells/uL, a new cycle of three IL-7 injections is simulated (single black vertical lines). A. Effect on both proliferation and loss rate of non-proliferating cells was full and constant during subsequent IL-7 cycles (scenario A-1 and A-2, see Table S4). B. The effect on proliferation during repeated cycles was assumed to be 50% of the one of the first cycle while the effect on loss rate was unchanged (scenario B-1 and B-2, see Table S4). Other parameters are presented in Table S1 (Model 2, dose 20), κ = 0.176.