Estimating the Probability of Polyreactive Antibodies 4E10 and 2F5 Disabling a gp41 Trimer after T Cell-HIV Adhesion
Figure 2
The probability of disabling an epitope, , versus the rate at which membrane fusion occurs,
, for different values of the disabling rate,
.
The probability was calculated from Eqs. (7) and (8) for two different 4E10 Fab concentrations, M in A and
M in B, using the parameter values given in Table 2. The values of
in
used to generate the various curves are given in the figures. The curves for
are indistinguishable. The top curves (solid black) in A and B each correspond to three curves generated for
,
and
.