Time Scales in Epigenetic Dynamics and Phenotypic Heterogeneity of Embryonic Stem Cells
Figure 8
Epigenetic landscapes and non-equilibrium curl fluxes derived from the transition diagrams in the differentiation process.
Contour maps of landscapes are shown on the two-dimensional plane of , the degree of closeness to the trophectoderm lineage, and
, the degree of closeness to the primitive endoderm lineage, and curl fluxes are shown with black lines on the landscapes with the width of lines representing the strength of fluxes; thick lines (
), lines with the middle width (
), and thin lines (
). (A–C) For the slow Nanog switching with
and
for other genes, and (D–F) for the fast Nanog switching with
for all genes. The rate of Oct4 synthesis is (A and D) same as other factors, and (B and E) 25% and (C and F) 10% of other factors.