Unraveling Adaptation in Eukaryotic Pathways: Lessons from Protocells
Figure 7
Sensitivity, response time and imprecision.
(a) Sensitivity, as defined in Fig. 1, for the one-component (light blue) and two-component (dark blue) models in response to a step increase of 50% in concentration, with prestimulus values from 0.01 to 100 mM. Bacterial chemotaxis (BC) and photo-transduction (PT) data of, respectively, receptor activity from in vivo FRET and transmembrane current are taken from Fig. 3B of [49] (20% step change) and Fig. 6B of [48]. (b) Response time, as defined in Fig. 1, and its dependence on the background stimulus. Shown are the one-component model (dashed line), two-component model (dark blue), as well as Dictyostelium data (DC) of ACA calculated from Fig. 4C of [25], olfactory-transduction transmembrane current data (OT) from Fig. 1a of [27], and photo-transduction transmembrane current data (PT) from Fig. 6B of [48]. (c) Imprecision, as defined in Fig. 1, for the one- and two-component model, BC data in response to MeAsp from Fig. 2c of [50], Dictyostelium data (DC) of ACA from Fig. 4C of [25] and transmembrane current PT data from Fig. 6B of [48].