A Brain-Machine Interface for Control of Medically-Induced Coma

doi:10.1371/journal.pcbi.1003284

A Brain-Machine Interface for Control of Medically-Induced Coma

Figure 5

Comparison of the bounded LQR and MPC strategies with upper-bound constraints on the drug infusion rates.

In each subfigure, the top panel shows the closed-loop controlled BSP traces using the bounded LQR control strategy and using the MPC strategy with various time horizons, time samples (seconds). The bottom panel shows the corresponding drug infusion rates. In addition to being non-negative, here the drug infusion rate is required to be less than 2.4 mg/min. Here we have shown two example permutations of the target levels but the bounded LQR and the MPC drug infusion rates converge with increasing in all cases.

doi: https://doi.org/10.1371/journal.pcbi.1003284.g005