A General Model for Toxin-Antitoxin Module Dynamics Can Explain Persister Cell Formation in E. coli
Figure 4
Conditional cooperativity has a larger influence on system dynamics in the interacting binding sites model.
The graphs show the time evolution of a single cell (color-coded towards the species plotted: free operator (gray), free antitoxin (green), free toxin (red)) as well as an average of 1000 cells (in black). A and C: three independent binding sites on the operator. B and D: Three interacting binding sites on the operator. A and B: with conditional cooperativity. C and D: without conditional cooperativity. No toxic feedback effects are included: .