Distinct Types of Disorder in the Human Proteome: Functional Implications for Alternative Splicing
Figure 6
Enrichment of driver cancer mutations in alternatively spliced regions.
A) Percentage of driver mutations that lie in different types of exons. A significant fraction of driver mutations falls within A, C1 and C2 exons. B) Ratio of driver to passenger mutations in different types of exons (A, C1 and C2 exons, distal C exons and rest of the exome). A significantly higher ratio of driver to passenger mutations is observed in A, C1 and C2 exons.