Synthetic Lethality between Gene Defects Affecting a Single Non-essential Molecular Pathway with Reversible Steps
Figure 1
Schematic representation of mechanisms of (A) between-pathways Synthetic Lethality, (B) within-pathway Synthetic Lethality, and (C) within-reversible-pathway Synthetic Lethality.
S: substrate, I: intermediate, P: product, C1–4: components of a protein complex. Red crosses define single mutations. For details see text.