A Computational Model Predicting Disruption of Blood Vessel Development
Figure 8
Quantitative analysis of 5HPP-33 exposure on simulated vascular plexus formation.
(A) Upper panel shows representative images of AngioTool analysis performed on control, 4.44 µM (5HPP-33 LC) and 40 µM (5HPP-33 HC) simulation outputs. Lower panel shows AngioTool analysis performed on donated experimental images for control, 3 µM 5HPP-33 and 30 µM 5HPP-33 exposure conditions. (B) Graphical representation of explant area, vessels area, vessels percentage area, number of vessel segments, branching index, and lacunarity values for the control model, 4.44 µM (5HPP-33 LC) and 40 µM (5HPP-33 HC). N = 30 simulations for each exposure scenario.