The Interaction of Vinculin with Actin
Figure 2
Interaction of Vt with actin along the filament.
The interaction between Vt (orange) and the F-actin is simulated using molecular dynamics. Vt forms two sets of interactions with F-actin along the filament: (1) an interaction with S3 of n-2 (top inset), (2) and interaction with S1 of n (bottom inset). Four interactions are formed between Vt and n-2: T1004 with K328, T1000 with R147, K996 with S145, and R963 with S350. Five interactions are formed between Vt and n: K996 with G48, E986 with R28, K996 with D51, T973 with R95, and R978 with E93. Actin subunit n is shown in blue, and subunit n-2 is shown in red.