Virus Neutralisation: New Insights from Kinetic Neutralisation Curves
Figure 3
Influence of different parameters on the kinetic neutralisation curves.
(A) Antibody starting concentration. The starting concentration of spikes is constant for all graphs, . The stoichiometry of entry is and the stoichiometry of trimer neutralisation . The binding constants are all and the dissociation constants are all . (B) Stoichiometry of entry. The parameters are the same as for (A) but the antibody starting concentration is . (C) and (D) Influence of the ratio between binding and dissociation constant in case all binding constants have the same value and all dissociation constants have the same value . In (C) the ratio between the binding and dissociation rates is kept constant at whereas in (D) the binding constant is kept constant at .