ProteinHistorian: Tools for the Comparative Analysis of Eukaryote Protein Origin
Figure 1
Data flow diagram representing the inputs and outputs for the ProteinHistorian analysis pipeline.
Three python programs (circles) perform the ProteinHistorian analyses. age_proteins.py analyzes cross-species protein family databases, such as those provided by PPOD or our domain database, and a corresponding species tree to estimate ages for all the proteins (bold). The resulting age databases are available for download and serve as the basis for all other analyses. Protein age distribution comparisons and enrichment tests, as in Figure 3, are performed by age_enrichment_analysis.py. Correlations between protein ages and other features, as in Figure 4, are computed by age_feature_analysis.py. The ProteinHistorian web server provides a user-friendly interface to many of the analyses performed by these programs.