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Standing Genetic Variation and the Evolution of Drug Resistance in HIV

Figure 6

The relationship between the length of a treatment interruption and the probability that DRMs become established.

Estimated probability that resistance mutations become established due to a single treatment interruption. Grey bars are data from seven clinical trials, estimated standard error (see supplementary table S3 in text S2). The number of patients (and the number of interruptions per patient) are noted at the top of the graph. The red circles are estimated from 1000 simulations, estimated standard error. The black squares are predictions using the average population size from the simulations and equation 2. Parameters as in table 2.

doi: https://doi.org/10.1371/journal.pcbi.1002527.g006