The Role of Non-Native Interactions in the Folding of Knotted Proteins
Figure 1
Knotted and unknotted carbamoyltransferases.
(a) Cartoon representation of the AOTCase which is natively-knotted in a right-handed trefoil knot (see sketch). The knotted region is highlighted in purple. (b) Cartoon representation of the unknotted OTCase. The MISTRAL structural alignment [39] of the knotted AOTCase and unknotted OTCase is shown in panel (c).