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Adjusting Phenotypes by Noise Control

Figure 8

Noise control in a metabolic network under end-product inhibition.

(a) The metabolic network is under stochastic fluctuations of an enzyme level . Other enzyme level fluctuations are neglected for simplicity. (b) Control analysis was applied to decrease the noise level of the end product, , without changing its mean level. Iterative small perturbations reduced the noise level significantly with a minor change in the mean level, as shown by the change in the probability distribution functions of . The original parameter values can be found in the caption of Fig. 7.

doi: https://doi.org/10.1371/journal.pcbi.1002344.g008