The Rates of Protein Synthesis and Degradation Account for the Differential Response of Neurons to Spaced and Massed Training Protocols
Figure 6
Modeling the rescue from desensitization by Anti-Desensitizer (AD) protein.
A, Model network pathways of AD desensitization protection pathway (red network designates AD pathway). B, PKC Apl II translocation in response to 5×5 min application of 5HT with 15 min washes in between and KT5720 present throughout from Farah et al. (2009) (bars) and modeling output (line). C, Top panel represents S dynamics in response to experimental protocol from B. Black line represents the ratio of SOFF and SON to total S and the red line the ratio of SIN2 to total S, and green line represents the ratio of SAD and SADON to total S. Bottom panel represents the amount of AD over time. D, PKC Apl II translocation in response to 90 min application of 5HT and KT5720 present throughout from Farah et al. (2009) (bars) and modeling output (line). E, Top panel represents S dynamics in response to experimental protocol from D. Line colours similar to in C.