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Evidence for Sequential and Increasing Activation of Replication Origins along Replication Timing Gradients in the Human Genome

Figure 6

Analysis of apparent replication speeds in multiple cell types.

The distribution of apparent replication speeds at the 100 kb scale in the whole genome was determined for (A) BG02, a human embryonic stem cell line; (B) K562, a chronic myelogenous leukemia cell line; (C) BJ, normal fibroblasts; (D) GM06990, (E) TL010, and (F) H0287, lymphoblastoid cell lines, as described for HeLa cells in Figure 3 legend.

Figure 6

doi: https://doi.org/10.1371/journal.pcbi.1002322.g006