Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps)
Figure 2
Box plot of classification accuracy with the number of selected side effects using a permutation test.
(a) The test consisted of 128 drugs with a ratio of 69 DILI positives versus 59 DILI negatives in the LTKB-BD, and (b) 258 drugs with a ratio of 168 DILI positive drugs and 90 DILI negative drugs in PfizerData. Given a randomly selected number of side effects, a drug showing positive in any of the side effects was considered as a DILI positive drug. The process was repeated 20,000 times for each of the selected number of side effects. The red dot denotes the data based on the 13 HepSEs selected from the MedDRA hepatobilliary disorders category.