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A Computational Approach to Finding Novel Targets for Existing Drugs

Figure 7

Docking icm- and pmf- scores for BIM-8 docked to 252 reliable-for-docking protein targets.

Each point represents a protein target. Targets for which BIM-8 passed a consensus threshold are shown as orange dots (top 5%) and brown dots (top 1%). Targets with experimental support are enclosed in red colors. Targets that have shown no binding activity with BIM-8 in the literature are shown in shades of green. It can be seen that most of the actual targets of BIM-8 pass stringent consensus score thresholds.

Figure 7

doi: https://doi.org/10.1371/journal.pcbi.1002139.g007