A Systems Biology Approach Identifies Molecular Networks Defining Skeletal Muscle Abnormalities in Chronic Obstructive Pulmonary Disease
Figure 4
Ingenuity networks regulated by endurance training.
This figure shows the most important findings derived from Ingenuity analysis using genes that are differentially expressed in response to training in healthy individuals and connected to receptor hubs in the previously inferred network. Panel A and Panel B represent two interconnected networks linked the transcription of several cytokines (IL1, TNFα, IFNγ, CCL2) and activation of the NF-kB complex (Panel A), leading to the activation of several NF-kB targets related to connective tissue formation (Panel B). Panel C shows the relationship between upregulation of gap junction complexes (JAM, JAM2, JAM3 and TJP1) and activation of important structural components of muscle fibres (e.g. tropomyosin). Panel D shows the important functional link between activation of several Rho GTPases and muscle development, represented by genes encoding for a component of the hexameric ATPase cellular motor protein myosin (MYL5) and MYH10.