Pharmacodynamic Modeling of Anti-Cancer Activity of Tetraiodothyroacetic Acid in a Perfused Cell Culture System
Figure 1
The perfusion bellows cell culture system.
Cells of cancer cell lines of interest are grown on plastic flakes suspended in a flow-through, bellows-agitated system that allows for homogeneous exposure of cells to drug/drug metabolite buffer solutions and air. The system permits frequent sampling of cells for viability. The direction of each arrow indicates the direction of influx and efflux of the culture medium. Components of system are not drawn to scale.