A Scalable Approach for Discovering Conserved Active Subnetworks across Species
Figure 3
Functional summaries of the subnetworks.
The 2D hierarchically clustered matrix of subnetworks' functions highlights functional enrichments based on Gene Ontology annotations (biological process category) for the mouse counterparts of all conserved active subnetworks. A subnetwork column is colored green if the subnetwork contained genes predominantly up-regulated in stem cells, red if the genes in the subnetwork are up-regulated in differentially expressed cells, and yellow, if the subnetwork contains mixed genes, some of which are more highly expressed in stem cells and some in differentiated cells. Enrichment was measured for all GO terms (Bonferroni-corrected p<0.05), and the enrichment patterns were clustered to reveal patterns of enrichment across the subnetworks. Enriched GO Terms for individual subnetworks have been uploaded on the subnetworks website and can be browsed at http://csbio.cs.umn.edu/neXus/subnetworks. The enriched GO Terms for stem cells, differentiated cells and mixed subnetworks can be found in Table S5.