A Systems Model for Immune Cell Interactions Unravels the Mechanism of Inflammation in Human Skin
Figure 12
Systems interpretation of pharmacological agent effects on inflamed tissue.
The majority of currently available pharmacological agents allow temporal elimination of inflammatory symptoms. In the context of the proposed systems model, this effect can be considered as a switch from the inflamed to perilesional steady-state (A). While such compounds or antibodies offer temporal relieve from inflammatory symptoms, they do not represent effective means of cure. The new pharmacological agents can be developed and selected on the action that leads to the disappearance of the additional inflammatory level (B).