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Systems Biology of Coagulation Initiation: Kinetics of Thrombin Generation in Resting and Activated Human Blood

Figure 2

Schematic of the Platelet-Plasma model.

(A) Wiring diagram of the Platelet-Plasma model. Blue highlighted portions represent additions to the Hockin-Mann model [18]. (B) Phosphatidylserine exposure measured by fold increase in annexin V binding was obtained from published values [60] and are shown in blue circles. The maximum platelet activation state attainable at a given thrombin concentration (εmax) was obtained by fitting a hill function to this data (green line). (C) The instantaneous platelet activation status (ε) approaches its maximum attainable value (εmax) on a time scale consistent with the time it takes for the platelet to mobilize intracellular calcium. Shown are ε transient profiles at various values of εmax. (See text for complete mathematical descriptions of εmax and ε).

Figure 2

doi: https://doi.org/10.1371/journal.pcbi.1000950.g002