Use of Data-Biased Random Walks on Graphs for the Retrieval of Context-Specific Networks from Genomic Data
Figure 5
p53-target cell cycle regulatory genes are specifically repressed during apoptosis.
A–B) Network plot of interactions in K3 (see Figure 4) related to cell cycle regulation. Nodes colored according to gene expression changes at 10 (A) or 1 µM (B) doxorubicin treatment. C) Western blots of p53, p21 (CDKN1A gene product) protein levels over a time course after 1 and 10µM doxorubicin treatment. Actin levels shown as control.