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Does Mutational Robustness Inhibit Extinction by Lethal Mutagenesis in Viral Populations?

Figure 3

Critical mutation rates in the neutral-staircase fitness landscape.

Critical mutations rates derived from Equation (5) are plotted as a function of the total number of blocks for varying numbers of active blocks . The critical mutation rates increase slowly as the number of active blocks increases. Parameters: number of bitpairs per block , reproductive capacity , between-block bitstring length .

Figure 3

doi: https://doi.org/10.1371/journal.pcbi.1000811.g003