Mathematical Modelling of Cell-Fate Decision in Response to Death Receptor Engagement
Figure 1
Regulatory networks of cell-fate decision.
(A) Master model: the molecular interactions between the main components intervening in the three pathways are described as an influence graph leading to the three cell fates: survival, non-apoptotic cell death and apoptosis. Dashed lines denote the pathway borders. (B) The corresponding reduced model.