Identifying the Rules of Engagement Enabling Leukocyte Rolling, Activation, and Adhesion
Figure 2
Diagrams illustrate the different spatial configurations of lfa1 and icam1 adhesion molecules implemented and tested during simulations.
lfa1Grids are shown with lfa1 objects labeled dark blue in either (A) a nonclustered state or (B) a clustered state. Clustered lfa1 are spatially restricted within the light blue region. Icam1Grids are shown with icam1 objects labeled yellow in either a (C) native monomeric state, (D) a native dimeric state, (E) as preformed clusters, or (F) as w-tetramers formed after ligand-binding.