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Spatial and Topological Organization of DNA Chains Induced by Gene Co-localization

Figure 8

Impact of genome organization on chromosome structure.

When several types (indicated by different colors of points) of binding sites are present, the specific positioning of the binding sites has a critical effect on the nature of the chromosomal structuring. For instance, binding sites that are ordered along the DNA according to their type, which can be viewed as a clustering of the binding sites along the DNA, favor the formation of rosettes. This is illustrated in the left panel (chromatin fiber, nm, nm, , , ). On the other hand, a periodic positioning tends to favor a solenoidal organization of the DNA as illustrated in the right panel (naked DNA. nm, , , ).

Figure 8

doi: https://doi.org/10.1371/journal.pcbi.1000678.g008