A Multi-Component Model of the Developing Retinocollicular Pathway Incorporating Axonal and Synaptic Growth
Figure 7
RGC axon development after blocking molecular guidance cues.
A. Axons from adjacent RGCs project to different collicular areas. Individual axon arbors refine, and neighboring RGCs tend to project to neighboring collicular neurons, but there is no continuity in the axonal projections. B. Map of the mature retinal projection (compare to Fig. 1F). Six RGCs are marked with different colors, and the center of their projective fields are shown in the colliculus. Global order is completely disrupted. Results from full-sized model are shown.