Circadian KaiC Phosphorylation: A Multi-Layer Network
Figure 7
Robustness in Kai reaction network.
(A) Resilience of Kai oscillator examined by mixing two anti-phased (trough and peak) samples with equal amount. The thin black and grey lines are the applied samples, and the bold black line the mixture. (B) Contour map of the initial reaction rate of Y after equal-amount sample mixing. The contour map is established in the interior region of the limit cycle of YS and YT. (C–D) Bifurcation analysis for the period (C) and amplitude (D) of KaiC phosphorylation by varying total Kai protein concentration. is the concentration of the standard mixture.