The Dynamics of T-Cell Receptor Repertoire Diversity Following Thymus Transplantation for DiGeorge Anomaly
Figure 1
Clone sizes, T cell concentrations and TCR repertoire diversity.
Clone sizes over time as computed under the model of Eqs.(1,4) (A–C) and the corresponding T cell concentrations (D) and TCR repertoire diversity (E) as a function of time past transplantation. computed under the model of Eqs.(1,4) as a function of time past transplantation. Parameter (see Model section) is varied as indicated while all other parameters are held constant. The higher
, the more limiting are TCR-specific resources. “Emigrant number” refers to the order in which clones leave the thymus and enter the periphery; emigrant number 1 is the first clone to arise, etc.