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Information Flow Analysis of Interactome Networks

Figure 5

Examples of proteins showing high information flow but low betweenness in the C. elegans interactome network.

The interactions in the C. elegans interactome do not have numerical confidence scores, and the discrepancy between information flow scores and betweenness is likely to be due to topological features such as the existence of alternative paths. KLC-1 (Panel A) and TAG-246 (Panel B) are two worm proteins that have only 4 interactions, and neither of them scores high in betweenness. However, KLC-1 rank the highest 37% and TAG-246 rank in the highest 26% in terms of the information flow scores. The two proteins both correspond to lethal phenotypes upon loss-of-function.

Figure 5

doi: https://doi.org/10.1371/journal.pcbi.1000350.g005