Distinct Modes of Regulation by Chromatin Encoded through Nucleosome Positioning Signals
Figure 1
Nucleosome organization at two genomic regions.
Shown are the raw data measured in this study at two 1000bp-long genomic regions. Every cyan oval represents the genomic location of one nucleosome that we sequenced in its entirety. Also shown is the average nucleosome occupancy per basepair predicted by the sequence-based nucleosome model that we developed here (red), the raw hybridization signal of two microarray-based nucleosome maps [5],[10] (green and purple traces), and the locations of nucleosomes that were computationally inferred from these hybridization signals [5],[10] (green and purple ovals). Note that although the nucleosome calls from the microarray maps are close to nucleosome locations from our map, the microarray map does not reveal the underlying variability in the detailed nucleosome read locations that we observe in our data. Annotated genes [63], transcription factor binding sites [47], TATA sequences [53], and Poly(dA:dT) elements in the region are also shown (top).