Modeling ChIP Sequencing In Silico with Applications
Figure 1
The genomic profile of ChIP-seq data.
(A) The signal profile map of STAT1 ChIP-seq data on human chromosome 22. (B) The same signal profile map in a small genomic region on human chromosome 22. (C) The sequence tags and the overlap profile of a tag cluster. This cluster, simplified as green lines in (A) and (B), is defined by 16 sequence tags, each of which is a uniquely mapped sequence read (dark green) plus its directional extension (light green). The outer and the inner forms of this cluster, bound by the two gray and the two white dashed lines respectively, have corresponding tag counts 16 and 12.