Classifying RNA-Binding Proteins Based on Electrostatic Properties
Figure 5
The largest electrostatic patch mapped on the protein structure of two RRM domains.
(A) The U2 snRNP A′ from the U2B″–U2A′ complex (1a9nA) and (B) the Y14 protein from the Y14-Magoh complex (1rk8A). Blue represents the largest electrostatic patch and green the RRM motif as defined by pfam. For the RNA-binding RRM domain the largest electrostatic patch overlaps the RNA-binding interface, while no overlap is observed between the largest electrostatic patch and the protein-protein interface of the Y14 protein. Notably, the largest positive patch is much smaller in the latter case.