Using Likelihood-Free Inference to Compare Evolutionary Dynamics of the Protein Networks of H. pylori and P. falciparum

doi:10.1371/journal.pcbi.0030230

Using Likelihood-Free Inference to Compare Evolutionary Dynamics of the Protein Networks of H. pylori and P. falciparum

Figure 2

Comparing Distance Functions on a Set of Summaries.

To compare different distance functions on sets of summaries, we analyzed the two-dimensional posterior support of θ for the H. pylori PIN dataset.

(A) α versus δ_Div and (B) α versus δ_Att. Using LFI with the set of summaries WR + DIA + CC + + FRAG, we recorded after burn-in the accepted parameters when each mean summary differed from the observed summary within the respective thresholds ɛ_k,_min (d_∩, red), and when the sum of these differences did not exceed the sum Σ_kɛ_k,_min of these thresholds (d_Σ, blue). In both cases, we used an average of shifted histograms to estimate the two-dimensional posterior support. When using d_∩, the posterior support was more restricted, prompting us to use d_∩ in LFI.

doi: https://doi.org/10.1371/journal.pcbi.0030230.g002