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Are There Rearrangement Hotspots in the Human Genome?

Figure 1

The Breakpoint Graph

The breakpoint graph G(P,Q) of a two-chromosomal genome P = (+ a + bc) (−d + e) and a unichromosomal genome Q = (+a + be + cd) represented as two black-obverse cycles and a gray-obverse cycle, correspondingly.

Figure 1

doi: https://doi.org/10.1371/journal.pcbi.0030209.g001