Optimal Noise Filtering in the Chemotactic Response of Escherichia coli
Figure 1
(A) E. coli swim towards nutrients via alternating running and tumbling movements. During each running period, the cell is aligned with the chemoattractant gradient with angle θi. These angles change abruptly after each tumble. However, rotational diffusion hinders the ability to swim in straight paths, so that the alignment angle varies stochastically.
(B) Chemotactic system. Chemoreceptor complexes contain the proteins CheA and CheW. Ligand–receptor interactions, stochastic in nature, affect the autophosphorylation of the kinase CheA (A), which is capable of transferring its phosphoryl group (P) to the protein CheY (Y). The phosphorylated form of CheY induces clockwise rotation of the flagella, causing tumbling. CheA also transfers phosphoryl groups to CheB (B), an enzyme responsible for demethylation of the receptor complex. Adaptation is achieved via the methylation of the receptor complex by CheR (R). Clockwise rotation of the flagella induces tumbling and a reorientation of the cell while CCW rotation propels the cell forward in a run. Swimming, affected by rotational and translational diffusion, leads the cell to new ligand concentrations in the environment.