A Community Resource Benchmarking Predictions of Peptide Binding to MHC-I Molecules
Figure 1
Comparability of the Binding Affinities between Assays
(A) Scatter plot comparing measured affinities for peptides to MHC recorded in the Buus (y-axis) and Sette (x-axis) assay systems.
(B) The agreement between experimental classifications of peptides as binders/nonbinders at different affinity thresholds (x-axis) is measured by the Matthews correlation coefficient (y-axis). The dashed lines indicates the IC50 = 500 nM cutoff commonly used for classifying peptides into binders and nonbinders, which is used in the ROC analysis.