Fold Designability, Distribution, and Disease
Figure 3
Family Occurrence and Family Counts of Ancient Folds
Ancient SCOP folds were divided into a number of bins according to the number of families that they contain (x-axis). For each bin, the mean family occurrence (the mean number of proteins in which the SCOP families in these folds appear) for human, mouse, and yeast proteins is shown. As the number of families in a SCOP fold increases, the occurrence of families belonging to these folds in the proteome tends to increase. Significant (MW-test, KS-test: p < 0.05) occurrence differences were found between folds of one and more than ten families in human and mouse. No significant differences were detected in yeast. The differences in mean family occurrence between mammals and yeast tend to be larger for folds with larger numbers of families. The differences in mean family occurrence between mammals and yeast tend to be larger for folds with larger numbers of families. These interspecies differences between folds of one family and those of more than one family are significant (MW-test: p < 0.1; KS-test: p < 0.001).