Calcineurin Mediates Synaptic Scaling Via Synaptic Trafficking of Ca2+-Permeable AMPA Receptors
Figure 5
Inhibition of calcineurin activity increased GluA1 surface trafficking by phosphorylation but decreases calcineurin.
(a) Representative immunoblots and quantitative analysis of synaptosomes from cultured cortical neurons in the presence and absence of FK506 treatment (n = 5 experiments, *p<.05, unpaired two-tailed Student's t test). (b) Representative immunoblots of surface biotinylation (D, DMSO; F, FK506) and a summary graph in the presence or absence of FK506 treatment (n = 6 experiments, *p<.05, unpaired two-tailed Student's t test).