In Silico Reconstitution of Actin-Based Symmetry Breaking and Motility
Figure 6
Increasing the degree of network crosslinking (PXL) causes a transition from smooth to pulsatile motion.
(A) Network morphologies and (B) bead velocities over time for values of PXL indicated. Very low crosslinking (PXL = 0.125) leads to no symmetry breaking. Low crosslinking (PXL = 0.375) bead oozes from network cloud. Higher crosslinking (PXL = 0.625) gives normal shell symmetry break and smooth motion, and very high crosslinking(PXL = 0.875) leads to repeated shell formation and pulsatile motion as the shells break.