Genetic Dissection of Behavioural and Autonomic Effects of Δ9-Tetrahydrocannabinol in Mice
Figure 5
Effect of THC on Body Temperature of Different CB1 Mutant Mice
Body temperature was measured with an infrared thermometer before injection (see text), 1 h (left panels) and 2 h (right panels) after the injection of 10 mg/kg of THC or vehicle. Values represent the difference of the body temperature of each animal with the mean of the respective vehicle-treated animals. *, **, ***; p < 0.05, p < 0.01, p < 0.001, respectively (two-way ANOVA, followed by Newman-Keuls post-hoc test). Note that THC has a normal effect in GABA-CB1−/− (A), but impaired (weaker and/or short lasting) effect in CaMK-CB1−/− (B), in Glu-CB1−/− (C), and in D1-CB1−/− mice (D). See Materials and Methods for number of animals in each group.