Drosophila Brakeless Interacts with Atrophin and Is Required for Tailless-Mediated Transcriptional Repression in Early Embryos
Figure 1
Severe Segmentation Defects in Embryos Derived from 2R-14 Germline Clones
Cuticle preparations of newly hatched embryos show three thoracic (T1–T3) and eight abdominal (A1–A8) ventral denticle belts in wt embryos (A). The embryo in (B) is derived from a germline clone homozygous for the original 2R-14 mutant chromosome arm. The phenotype is intermediate to that of gap and pair-rule mutants, with several abdominal denticle belts missing. There is some variation from embryo to embryo with regard to which particular denticle belts are missing, but 100% of the embryos display a segmentation phenotype. Shown in (C) is an embryo derived from germline clones in which the 2R-14 chromosome has been cleaned by recombination. The phenotypes of these embryos are indistinguishable from those derived from the original 2R-14 chromosome. Embryos derived from bks1 germline clones (D) display phenotypes virtually identical to those in 2R-14 mutant embryos.