Stratus Not Altocumulus: A New View of the Yeast Protein Interaction Network
Figure 4
Network Tolerance to Hub Deletion
The size of the largest component after deletion of hubs in the indicated networks was normalized by the initial size of the largest component. In all cases, hubs were deleted in descending order of connectivity.
(A) The FYI network is sensitive to hub deletions, whereas the HCfyi network is tolerant to hub deletions.
(B) Topological sensitivity to node deletion can be modulated by varying the fraction of hub–hub interactions. Addition of 10% of random hub–hub interactions is sufficient to increase the tolerance of the FYI network to hub deletion (“augmented”). Deletion of 40% of interactions among hubs is necessary to increase the sensitivity of the HCfyi network to hub deletion (“reduced”).