Developmental Context Determines Latency of MYC-Induced Tumorigenesis
Figure 6
MYC Activation in Adult Hepatocytes Induces Increased Cell Size and Endoreduplication, and Only Results in Cell Proliferation upon Neoplastic Conversion of Hepatocytes
(A) Histology of a normal liver.
(B) Histology of a liver 2 months after MYC activation.
(C) Histology of a MYC-induced liver tumor.
(D and G) Ki67 immunofluorescence and DAPI staining of a normal adult liver.
(E and H) Ki67 and DAPI staining of an adult liver after 8 weeks of MYC activation.
(F and I) Ki67 and DAPI staining of a MYC-induced adult tumor.
(J) DNA content measured in normal hepatocytes.
(K) DNA content measured after MYC induction for 2 months.
(L) DNA content of a representative MYC-induced liver tumor.