Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution
Figure 4
Independent Confirmation of Interspecies cDNA aCGH Data for Three Gene Families with Known Species Differences in Copy Number
The chromosomal location, IMAGE clone ID, and GenBank accession are provided for each cDNA. The species average log2 ratios for each cDNA clone and the previously published estimate of gene copy number are shown for the indicated species. Also shown are TreeView images of interhominoid aCGH results for the indicated cDNAs, and a graphical depiction of the correlation between aCGH signal and published estimate of gene copy number (PECN).
(A) FGF7 cDNA clone located on human Chromosome 15 was identified using the UCSC November 2002 human genome assembly and FGF7-like cDNA clones located on human Chromosome 9 were identified based on UniGene cluster sequence similarity to FGF7 reference sequence NM_002009. The correlation between published and aCGH-based copy number estimates is 0.97.
(B) morpheus family cDNA clones were identified based on sequence similarity to one morpheus family member (Johnson et al. 2001). As in (A), except data relate to the morpheus genes and published data are from Johnson et al. (2001). Correlation = 0.97.
(C) As in (A), except data relate to the CXYorf1 genes and published data are from Ciccodicola et al. (2000). Correlation = 0.99.