Noise Minimization in Eukaryotic Gene Expression
Figure 2
Essential Genes and Protein Complex Subunits Minimize Noise in Expression
Binning analysis of (A) essential genes and (B) protein complex subunits. All genes for which transcription and translation rate data were available were separated into 15 bins by their protein production rate. Each bin was then separated into thirds by number of translations per mRNA. The two-thirds in each bin with the most extreme transcription and translation are shown: black bars are the number of each type of gene (essential or complex subunit) in the third of each bin with the lowest number of translations per mRNA and the highest transcription rate, and thus low noise; gray bars are the number of each type of gene in the third with the highest number of translations per mRNA and the lowest transcripton rate, and thus high noise. Bins are ordered by their rate of protein synthesis. The number of asterisks indicates the Fisher's exact test probability of observing the values for each bin under the null model of independence. *, p ≤ 0.02; **, p < 0.005; ***, p < 0.0005.